TARGETID

T37245

FORMERID

TTDC00241

UNIPROID

DDIT4_HUMAN

TARGNAME

RTP801 messenger RNA (RTP801 mRNA)

GENENAME

DDIT4

TARGTYPE

Clinical trial target

SYNONYMS

RTP801 (mRNA); REDD1 (mRNA); REDD-1 (mRNA); Protein regulated in development and DNA damage response 1 (mRNA); HIF-1 responsive protein RTP801 (mRNA); DNA damage-inducible transcript 4 protein (mRNA)

FUNCTION

Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Required for mTORC1-mediated defense against viral protein synthesis and virus replication. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1).

PDBSTRUC

3LQ9

BIOCLASS

mRNA target

SEQUENCE

MPSLWDRFSSSSTSSSPSSLPRTPTPDRPPRSAWGSATREEGFDRSTSLESSDCESLDSSNSGFGPEEDTAYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLAQARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVGQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLFSSANSPFLPGFSQSLTLSTGFRVIKKKLYSSEQLLIEEC

DRUGINFO

PF-4523655

KEGGPATH

hsa04150:mTOR signaling pathway

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa05206:MicroRNAs in cancer

WIKIPATH

WP1471:TOR Signaling

REACPATH

R-HSA-5628897:TP53 Regulates Metabolic Genes

NET_PATH

NetPath_16:IL4 Signaling Pathway

NET_PATH

NetPath_7:TGF_beta_Receptor Signaling Pathway

INTEPATH

mtor_4pathway:mTOR signaling pathway