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靶点信息

标题

内容

相关药物

状态

TARGETID

T37046

FORMERID

TTDS00494

UNIPROID

BIEA_HUMAN

TARGNAME

Biliverdin reductase A (BLVRA)

GENENAME

BLVRA

TARGTYPE

Successful target

SYNONYMS

Biliverdin-IX alpha-reductase; BVR A; BVR; BLVRA; BLVR

FUNCTION

Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.

PDBSTRUC

2H63

BIOCLASS

CH-CH donor oxidoreductase

ECNUMBER

EC 1.3.1.24

SEQUENCE

MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLEDALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKVLHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLFGELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLENVPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK

DRUGINFO

D0G3SH

Ursodeoxycholic acid

Approved

DRUGINFO

D0R6JE

Nicotinamide-Adenine-Dinucleotide

Investigative

KEGGPATH

hsa00860:Porphyrin and chlorophyll metabolism

WHIZPATH

PW000158:Porphyrin Metabolism

BIOCPATH

PWY-5874:Heme degradation

目标的 KEGG 通路数据

标题	内容
hsa00860	Porphyrin and chlorophyll metabolism

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T37046
UNIPROID	BIEA_HUMAN
TARGNAME	Biliverdin reductase A (BLVRA)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Biliverdin reductase A (BLVRA)	MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLEDALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKVLHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLFGELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLENVPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK

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