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靶点信息55(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Peroxisome proliferator-activated receptor delta (PPARD)
TARGTYPE
Clinical trial target
SYNONYMS
Peroxisomeproliferator-activated receptor beta; Peroxisomeproliferator activated receptor beta/delta; Peroxisome proliferator-activated receptor beta; PPARdelta; PPARB; PPAR-delta; PPAR-beta; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUCI; NUC1; NR1C2
FUNCTION
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Ligand-activated transcription factor.
PDBSTRUC
5ZXI; 5Y7X; 5XMX; 5U46; 5U45
BIOCLASS
Nuclear hormone receptor
SEQUENCE
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
DRUGINFO
PMID25416646-Compound-Figure5-C
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa03320 |
|
| hsa04310 |
|
| hsa05200 |
|
| hsa05221 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP399 |
|
| WP299 |
|
| WP2884 |
|
| WP2882 |
|
| WP2877 |
|
| WP2858 |
|
| WP236 |
|
| WP170 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Peroxisome proliferator-activated receptor delta (PPARD) |
|