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靶点信息13(本栏目收费,不能显示细节,电话13136136841)

靶点信息

标题

内容

相关药物

状态

TARGETID

T35792

UNIPROID

SMYD3_HUMAN

TARGNAME

Histone-lysine N-methyltransferase SMYD3 (SMYD3)

GENENAME

SMYD3

TARGTYPE

Preclinical target

SYNONYMS

SET and MYND domain-containing protein 3; Zinc finger MYND domain-containing protein 1

FUNCTION

Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation . Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.

ECNUMBER

EC 2.1.1.354

SEQUENCE

MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS

DRUGINFO

EPZ028862

DRUGINFO

EPZ031686

DRUGINFO

EPZ0330456

DRUGINFO

GSK2807

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T35792
UNIPROID	SMYD3_HUMAN
TARGNAME	Histone-lysine N-methyltransferase SMYD3 (SMYD3)
TARGTYPE	Preclinical target

目标的序列数据

标题	内容
Histone-lysine N-methyltransferase SMYD3 (SMYD3)	MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS

标题

内容

Histone-lysine N-methyltransferase SMYD3 (SMYD3)

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