靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T35486

FORMERID

TTDI01767

UNIPROID

RASN_HUMAN

TARGNAME

GTPase NRas (NRAS)

GENENAME

NRAS

TARGTYPE

Clinical trial target

SYNONYMS

Transforming protein N-Ras; HRAS1

FUNCTION

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

PDBSTRUC

5UHV; 3CON; 2N9C

BIOCLASS

Small GTPase

SEQUENCE

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM

DRUGINFO

GI-4000

DRUGINFO

Mutant ras vaccine

DRUGINFO

Reovirus

DRUGINFO

Salirasib

DRUGINFO

Perillyl alcohol

Discontinued in Phase 2

DRUGINFO

APC-300

DRUGINFO

KA-10X

WIKIPATH

WP1794:Cell surface interactions at the vascular wall

WIKIPATH

WP1840:Interleukin-3, 5 and GM-CSF signaling

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容
WP1916	Signaling by PDGF
WP1913	Signaling by Insulin receptor
WP1911	Signaling by FGFR
WP1910	Signaling by EGFR
WP1873	NGF signalling via TRKA from the plasma membrane
WP1866	NCAM signaling for neurite out-growth
WP185	Integrin-mediated Cell Adhesion
WP1840	Interleukin-3, 5 and GM-CSF signaling
WP1794	Cell surface interactions at the vascular wall
WP732	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
WP710	DNA Damage Response (only ATM dependent)
WP69	TCR Signaling Pathway
WP673	ErbB Signaling Pathway
WP615	Senescence and Autophagy in Cancer
WP560	TGF Beta Signaling Pathway
WP49	IL-2 Signaling Pathway
WP481	Insulin Signaling
WP437	EGF/EGFR Signaling Pathway
WP422	MAPK Cascade
WP400	p38 MAPK Signaling Pathway
WP35	G Protein Signaling Pathways
WP313	Signaling of Hepatocyte Growth Factor Receptor
WP304	Kit receptor signaling pathway
WP2870	Extracellular vesicle-mediated signaling in recipient cells
WP286	IL-3 Signaling Pathway
WP2828	Bladder Cancer
WP2781	Signaling by ERBB4
WP2780	Signaling by ERBB2
WP2759	Fc epsilon receptor (FCERI) signaling
WP2754	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP2746	Signaling by the B Cell Receptor (BCR)
WP2735	RAF/MAP kinase cascade
WP2732	Interleukin-2 signaling
WP2713	Signaling by SCF-KIT
WP2694	DAP12 interactions
WP2677	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP2643	Nanoparticle-mediated activation of receptor signaling
WP2593	JAK/STAT
WP2586	Aryl Hydrocarbon Receptor
WP2526	PDGF Pathway
WP244	Alpha 6 Beta 4 signaling pathway
WP2380	BDNF signaling pathway
WP2374	Oncostatin M Signaling Pathway
WP2332	Interleukin-11 Signaling Pathway
WP231	TNF alpha Signaling Pathway
WP23	B Cell Receptor Signaling Pathway
WP2290	RalA downstream regulated genes
WP2263	Prostate Cancer
WP2261	Signaling Pathways in Glioblastoma
WP2034	Leptin signaling pathway
WP2032	TSH signaling pathway

目标的蛋白质ID

标题	内容
TARGETID	T35486
UNIPROID	RASN_HUMAN
TARGNAME	GTPase NRas (NRAS)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
GTPase NRas (NRAS)	MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM

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