TARGETID

T34234

FORMERID

TTDS00251

UNIPROID

VDR_HUMAN

TARGNAME

Vitamin D3 receptor (VDR)

GENENAME

VDR

TARGTYPE

Successful target

SYNONYMS

Vitamin D(3) receptor; Nuclear vitamin D receptor; Nuclear receptor subfamily 1 group I member 1; NR1I1; 1,25-dihydroxyvitamin D3 receptor

FUNCTION

Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells.

PDBSTRUC

5YT2; 5YSY; 5V39; 5GT4; 4ITF

BIOCLASS

Nuclear hormone receptor

SEQUENCE

MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS

DRUGINFO

Calcidiol

DRUGINFO

Calcipotriol

DRUGINFO

Calcitriol

DRUGINFO

Cholecalciferol

DRUGINFO

Dihydrotachysterol

DRUGINFO

Doxercalciferol

DRUGINFO

Ergocalciferol

DRUGINFO

Falecalcitrol

DRUGINFO

Paricalcitol