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靶点信息84(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Epidermal growth factor (EGF)
TARGTYPE
Successful target
SYNONYMS
Proepidermal growth factor; Pro-epidermal growth factor
FUNCTION
Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro. EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.
PDBSTRUC
3NJP; 2KV4; 1P9J; 1NQL; 1JL9
SEQUENCE
MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ
DRUGINFO
Epidermal growth factor
KEGGPATH
hsa04010:MAPK signaling pathway
KEGGPATH
hsa04012:ErbB signaling pathway
KEGGPATH
hsa04014:Ras signaling pathway
KEGGPATH
hsa04015:Rap1 signaling pathway
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04066:HIF-1 signaling pathway
KEGGPATH
hsa04068:FoxO signaling pathway
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04010 |
|
| hsa04012 |
|
| hsa04014 |
|
| hsa04015 |
|
| hsa04060 |
|
| hsa04066 |
|
| hsa04068 |
|
| hsa04144 |
|
| hsa04151 |
|
| hsa04510 |
|
| hsa04540 |
|
| hsa04810 |
|
| hsa05160 |
|
| hsa05200 |
|
| hsa05212 |
|
| hsa05213 |
|
| hsa05214 |
|
| hsa05215 |
|
| hsa05218 |
|
| hsa05219 |
|
| hsa05223 |
|
| hsa05231 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP673 |
|
| WP560 |
|
| WP51 |
|
| WP437 |
|
| WP382 |
|
| WP306 |
|
| WP2849 |
|
| WP2848 |
|
| WP2828 |
|
| WP2804 |
|
| WP2795 |
|
| WP2781 |
|
| WP2780 |
|
| WP2653 |
|
| WP2593 |
|
| WP2571 |
|
| WP2377 |
|
| WP1910 |
|
| WP1544 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Epidermal growth factor (EGF) |
|