TARGETID

T32578

FORMERID

TTDC00080

UNIPROID

IL6_HUMAN

TARGNAME

Interleukin-6 (IL6)

GENENAME

IL6

TARGTYPE

Successful target

SYNONYMS

Interferon beta-2; IL-6; IFNB2; IFN-beta-2; Hybridoma growth factor; CTL differentiation factor; CDF; BSF-2; B-cell stimulatory factor 2

FUNCTION

It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. Cytokine with a wide variety of biological functions.

PDBSTRUC

5FUC; 4ZS7; 4O9H; 4NI9; 4NI7

BIOCLASS

Cytokine: interleukin

SEQUENCE

MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

DRUGINFO

Siltuximab

DRUGINFO

Olokizumab

DRUGINFO

Sirukumab

DRUGINFO

ALD-518

DRUGINFO

CDP-6038

DRUGINFO

Clazakizumab

DRUGINFO

PF-04236921

DRUGINFO

YSIL6

DRUGINFO

C326