靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T32282

FORMERID

TTDR00418

UNIPROID

PRL_HUMAN

TARGNAME

Prolactin (PRL)

GENENAME

PRL

TARGTYPE

Discontinued target

SYNONYMS

GHA1

FUNCTION

Prolactin acts primarily on the mammary gland by promoting lactation.

PDBSTRUC

3NPZ; 3NCF; 3NCE; 3NCC; 3NCB

BIOCLASS

Somatotropin/prolactin

SEQUENCE

MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

DRUGINFO

D0F2IC

NTx-488

Discontinued in Phase 2

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04080:Neuroactive ligand-receptor interaction

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04630:Jak-STAT signaling pathway

KEGGPATH

hsa04917:Prolactin signaling pathway

WIKIPATH

WP2593:JAK/STAT

WIKIPATH

WP2657:Growth hormone receptor signaling

WIKIPATH

WP2678:Prolactin receptor signaling

目标的 KEGG 通路数据

标题	内容
hsa04060	Cytokine-cytokine receptor interaction
hsa04080	Neuroactive ligand-receptor interaction
hsa04151	PI3K-Akt signaling pathway
hsa04630	Jak-STAT signaling pathway
hsa04917	Prolactin signaling pathway

目标的 Wiki 路径数据

标题	内容
WP98	Prostaglandin Synthesis and Regulation
WP3297	EV release from cardiac cells and their functional effects
WP2678	Prolactin receptor signaling
WP2657	Growth hormone receptor signaling
WP2593	JAK/STAT

目标的蛋白质ID

标题	内容
TARGETID	T32282
UNIPROID	PRL_HUMAN
TARGNAME	Prolactin (PRL)
TARGTYPE	Discontinued target

目标的序列数据

标题	内容
Prolactin (PRL)	MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

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