TARGETID

T32262

FORMERID

TTDC00093

UNIPROID

CALRL_HUMAN

TARGNAME

Calcitonin gene-related peptide receptor (CGRPR)

GENENAME

CALCRL

SYNONYMS

Calcitonin receptor-like receptor; Calcitonin gene-related peptide type 1 receptor; CGRPR; CGRP type 1 receptor

FUNCTION

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

PDBSTRUC

6E3Y; 6D1U; 5V6Y; 4RWG; 4RWF

BIOCLASS

GPCR secretin

SEQUENCE

MEKKCTLNFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN

DRUGINFO

Erenumab

DRUGINFO

Fremanezumab

DRUGINFO

Galcanezumab

DRUGINFO

Rimegepant

DRUGINFO

Ubrogepant

DRUGINFO

AMG 334

DRUGINFO

BI-44370

DRUGINFO

MK-3207

DRUGINFO

Olcegepant

DRUGINFO

Telcagepant