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靶点信息

标题

内容

相关药物

状态

TARGETID

T31825

FORMERID

TTDI01041

UNIPROID

HBB_HUMAN

TARGNAME

Hemoglobin subunit beta (HBB)

GENENAME

HBB

TARGTYPE

Clinical trial target

SYNONYMS

LVVhemorphin7; Hemoglobin beta chain; Betaglobin; Beta-globin

FUNCTION

Involved in oxygen transport from the lung to the various peripheral tissues.

PDBSTRUC

6NBD; 6NBC; 6HBW; 6HAL; 6FQF

BIOCLASS

Pore-forming globin

SEQUENCE

MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH

DRUGINFO

LentiGlobin

DRUGINFO

OTL-300

KEGGPATH

hsa05143:African trypanosomiasis

KEGGPATH

hsa05144:Malaria

WIKIPATH

WP15:Selenium Micronutrient Network

WIKIPATH

WP1533:Vitamin B12 Metabolism

WIKIPATH

WP176:Folate Metabolism

WIKIPATH

WP1815:Factors involved in megakaryocyte development and platelet production

WIKIPATH

WP2681:Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes

目标的 KEGG 通路数据

标题	内容
hsa05143	African trypanosomiasis
hsa05144	Malaria

目标的 Wiki 路径数据

标题	内容
WP15	Selenium Micronutrient Network
WP2784	Binding and Uptake of Ligands by Scavenger Receptors
WP2744	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
WP2681	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
WP1815	Factors involved in megakaryocyte development and platelet production
WP176	Folate Metabolism
WP1533	Vitamin B12 Metabolism

目标的蛋白质ID

标题	内容
TARGETID	T31825
UNIPROID	HBB_HUMAN
TARGNAME	Hemoglobin subunit beta (HBB)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Hemoglobin subunit beta (HBB)	MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH

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