靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T31621

FORMERID

TTDR00567

UNIPROID

FGF2_HUMAN

TARGNAME

Fibroblast growth factor-2 (FGF2)

GENENAME

FGF2

TARGTYPE

Successful target

SYNONYMS

bFGF; Heparin-binding growth factor 2; HBGF-2; Fibroblast growth factor 2; FGFB; FGF-2; Basic fibroblast growth factor

FUNCTION

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.

PDBSTRUC

5X1O; 4OEG; 4OEF; 4OEE; 4FGF

BIOCLASS

Growth factor

SEQUENCE

MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS

DRUGINFO

Sucralfate

DRUGINFO

Squalamine

DRUGINFO

Bemarituzumab

DRUGINFO

DVC1-0101

DRUGINFO

FPA144

DRUGINFO

TGP-580

Discontinued in Phase 2

DRUGINFO

D09ZAV

RG-8803

Terminated

DRUGINFO

D0X4AL

1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid

Investigative

DRUGINFO

D0KL1I

1,4-Dideoxy-O2-Sulfo-Glucuronic Acid

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04010	MAPK signaling pathway
hsa04014	Ras signaling pathway
hsa04015	Rap1 signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04810	Regulation of actin cytoskeleton
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer
hsa05218	Melanoma

目标的 Wiki 路径数据

标题	内容
WP51	Regulation of Actin Cytoskeleton
WP474	Endochondral Ossification
WP2848	Differentiation Pathway
WP2795	Cardiac Hypertrophic Response
WP2787	Syndecan interactions
WP2703	Extracellular matrix organization
WP2677	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
WP2653	PIP3 activates AKT signaling
WP2406	Cardiac Progenitor Differentiation
WP2377	Integrated Pancreatic Cancer Pathway
WP2064	Neural Crest Differentiation
WP2006	miR-targeted genes in squamous cell - TarBase
WP2005	miR-targeted genes in muscle cell - TarBase
WP2004	miR-targeted genes in lymphocytes - TarBase
WP1911	Signaling by FGFR
WP1544	MicroRNAs in cardiomyocyte hypertrophy
WP1539	Angiogenesis

目标的蛋白质ID

标题	内容
TARGETID	T31621
UNIPROID	FGF2_HUMAN
TARGNAME	Fibroblast growth factor-2 (FGF2)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Fibroblast growth factor-2 (FGF2)	MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS

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