TARGETID

T30985

FORMERID

TTDS00087

UNIPROID

HRH2_HUMAN

TARGNAME

Histamine H2 receptor (H2R)

GENENAME

HRH2

TARGTYPE

Successful target

SYNONYMS

Histamine receptor 2; HH2R; Gastric receptor I

FUNCTION

Appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. The H2 subclass of histamine receptors mediates gastric acid secretion.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR

DRUGINFO

Betazole

DRUGINFO

Cimetidine

DRUGINFO

Famotidine

DRUGINFO

Nizatidine

DRUGINFO

Ranitidine

DRUGINFO

Ebrotidine

DRUGINFO

KU-1257

DRUGINFO

Osutidine

DRUGINFO

Pibutidine

DRUGINFO

IGN-2098