靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T30823

FORMERID

TTDR00202

UNIPROID

MPIP1_HUMAN

TARGNAME

M-phase inducer phosphatase 1 (MPIP1)

GENENAME

CDC25A

TARGTYPE

Literature-reported target

SYNONYMS

Dual specificity phosphatase Cdc25A; Cdc25A phosphatase

FUNCTION

Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro. Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.

PDBSTRUC

1C25

BIOCLASS

Phosphoric monoester hydrolase

ECNUMBER

EC 3.1.3.48

SEQUENCE

MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL

DRUGINFO

MX-7065

DRUGINFO

Ro 20-1724

DRUGINFO

(E)-2-(1-decyl-2-oxoindolin-3-ylidene)acetic acid

Investigative

DRUGINFO

D0W1SP

(Z)-2-(1-decyl-2-oxoindolin-3-ylidene)acetic acid

Investigative

DRUGINFO

D00ANJ

1-dodecyl-1H-indole-2,3-dione

Investigative

DRUGINFO

D0CJ6P

2-(1-dodecyl-1H-indol-3-yl)acetic acid

Investigative

DRUGINFO

D0X5WD

3-isopropyl-4-(phenylamino)naphthalene-1,2-dione

Investigative

DRUGINFO

D08GWQ

3-isopropyl-4-(phenylthio)naphthalene-1,2-dione

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04110	Cell cycle
hsa04914	Progesterone-mediated oocyte maturation
hsa05206	MicroRNAs in cancer

目标的 Wiki 路径数据

标题	内容
WP707	DNA Damage Response
WP45	G1 to S cell cycle control
WP2772	S Phase
WP2516	ATM Signaling Pathway
WP2446	Retinoblastoma (RB) in Cancer
WP2263	Prostate Cancer
WP1984	Integrated Breast Cancer Pathway
WP1971	Integrated Cancer pathway
WP1858	Mitotic G1-G1/S phases
WP179	Cell Cycle
WP1775	Cell Cycle Checkpoints
WP1545	miRNAs involved in DNA damage response
WP1530	miRNA Regulation of DNA Damage Response

目标的蛋白质ID

标题	内容
TARGETID	T30823
UNIPROID	MPIP1_HUMAN
TARGNAME	M-phase inducer phosphatase 1 (MPIP1)
TARGTYPE	Research target

目标的序列数据

标题	内容
M-phase inducer phosphatase 1 (MPIP1)	MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL

标题

内容

M-phase inducer phosphatase 1 (MPIP1)

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