靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T30803

FORMERID

TTDI00816

UNIPROID

GSHR_HUMAN

TARGNAME

Glutathione reductase (GR)

GENENAME

GSR

TARGTYPE

Patented-recorded target

SYNONYMS

Glutathione reductase, mitochondrial; GRase; GRD1; GLUR

FUNCTION

Maintains high levels of reduced glutathione in the cytosol.

PDBSTRUC

5GRT; 4GRT; 4GR1; 3SQP; 3GRT

BIOCLASS

Sulfur donor oxidoreductase

ECNUMBER

EC 1.8.1.7

SEQUENCE

MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

DRUGINFO

D0V4TY

Oxidized glutathione

Approved

DRUGINFO

D0Z2MX

Acyl oxymethyl acrylamide ester derivative 1

Patented

DRUGINFO

D0W1DK

Golden phosphorous acetyletic compound 1

Patented

DRUGINFO

D02NYT

Golden phosphorous acetyletic compound 2

Patented

DRUGINFO

D03BPZ

Terpyridineplatinum(II) complexe 3

Patented

DRUGINFO

D05SHW

Terpyridineplatinum(II) complexe 4

Patented

DRUGINFO

D0I8HK

1-(2'-chlorophenyl)penta-1,4-dien-3-one

Investigative

DRUGINFO

D0YQ0G

2,4,6 trinitrobenzene sulfonate 1,3-bis (2-chlorethyl)-1-nitrosourea

Investigative

目标的 KEGG 通路数据

标题	内容
hsa00480	Glutathione metabolism
hsa04918	Thyroid hormone synthesis

目标的 Wiki 路径数据

标题	内容
WP702	Metapathway biotransformation
WP692	Sulfation Biotransformation Reaction
WP408	Oxidative Stress
WP2884	NRF2 pathway
WP2882	Nuclear Receptors Meta-Pathway
WP15	Selenium Micronutrient Network
WP100	Glutathione metabolism

目标的蛋白质ID

标题	内容
TARGETID	T30803
UNIPROID	GSHR_HUMAN
TARGNAME	Glutathione reductase (GR)
TARGTYPE	Patented target

目标的序列数据

标题	内容
Glutathione reductase (GR)	MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

标题

内容

Glutathione reductase (GR)

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