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靶点信息50(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Thrombospondin-1 (THBS1)
TARGTYPE
Clinical trial target
SYNONYMS
TSP1; TSP; Glycoprotein G
FUNCTION
Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors. Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.
PDBSTRUC
5FOE; 3R6B; 2OUJ; 2OUH; 2ES3
SEQUENCE
MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRDP
KEGGPATH
hsa04015:Rap1 signaling pathway
KEGGPATH
hsa04115:p53 signaling pathway
KEGGPATH
hsa04145:Phagosome
KEGGPATH
hsa04151:PI3K-Akt signaling pathway
KEGGPATH
hsa04350:TGF-beta signaling pathway
KEGGPATH
hsa04510:Focal adhesion
KEGGPATH
hsa04512:ECM-receptor interaction
KEGGPATH
hsa05144:Malaria
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04510 |
|
| hsa04512 |
|
| hsa05144 |
|
| hsa05205 |
|
| hsa05206 |
|
| hsa05219 |
|
| hsa04015 |
|
| hsa04115 |
|
| hsa04145 |
|
| hsa04151 |
|
| hsa04350 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP615 |
|
| WP560 |
|
| WP453 |
|
| WP366 |
|
| WP306 |
|
| WP2911 |
|
| WP2864 |
|
| WP2828 |
|
| WP2806 |
|
| WP2787 |
|
| WP2377 |
|
| WP2006 |
|
| WP2005 |
|
| WP2003 |
|
| WP1916 |
|
| WP1833 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Thrombospondin-1 (THBS1) |
|