TARGETID

T30731

FORMERID

TTDR00406

UNIPROID

KNG1_HUMAN

TARGNAME

Kininogen (KNG1)

GENENAME

KNG1

TARGTYPE

Clinical trial target

SYNONYMS

KNG1; Bradykinin

FUNCTION

Kininogens are inhibitors of thiol proteases; hmw-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor xi next to factor xii; hmw-kininogen inhibits the thrombin-and plasmin- induced process.

PDBSTRUC

6F3Y; 6F3X; 6F3W; 6F3V; 6F27

SEQUENCE

MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPWEKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSGKEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLDDDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQEKTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSFNPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS

DRUGINFO

Avoralstat

DRUGINFO

CU201 (B9870)

KEGGPATH

hsa04610:Complement and coagulation cascades

WIKIPATH

WP1818:Formation of Fibrin Clot (Clotting Cascade)

WIKIPATH

WP1824:GPCR downstream signaling

WIKIPATH

WP1825:GPCR ligand binding

WIKIPATH

WP2664:Gastrin-CREB signalling pathway via PKC and MAPK

WIKIPATH

WP2877:Vitamin D Receptor Pathway

WIKIPATH

WP554:ACE Inhibitor Pathway

WIKIPATH

WP558:Complement and Coagulation Cascades