TARGETID

T30635

FORMERID

TTDR00498

UNIPROID

CXL10_HUMAN

TARGNAME

C-X-C motif chemokine 10 (CXCL10)

GENENAME

CXCL10

TARGTYPE

Clinical trial target

SYNONYMS

Small-inducible cytokine B10; SCYB10; IP-10; INP10; Gamma-IP10; 10 kDa interferon gamma-induced protein

FUNCTION

Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).

PDBSTRUC

1O80; 1O7Z; 1O7Y; 1LV9

BIOCLASS

Cytokine: CXC chemokine

SEQUENCE

MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP

DRUGINFO

Anti-IP10

DRUGINFO

BMS-936557

DRUGINFO

JT02

DRUGINFO

MDX-1100

DRUGINFO

NI-0801

DRUGINFO

NG-641

DRUGINFO

N-Methylleucine

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04062:Chemokine signaling pathway