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靶点信息30(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Interferon gamma receptor (IFNGR2)
TARGTYPE
Successful target
SYNONYMS
Interferon gamma transducer 1; Interferon gamma receptor beta-chain; Interferon gamma receptor accessory factor 1; Interferon gamma receptor 2; IFNGT1; IFNGR; IFN-gamma-R2; IFN-gamma-R-beta; IFN-gamma-R; IFN-gamma receptor 2; CDw119; CD119; AF-1
FUNCTION
Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding. Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (, ,).
PDBSTRUC
6E3L; 6E3K; 5EH1
BIOCLASS
Cytokine receptor
SEQUENCE
MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRPVVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELGALHSAWVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL
DRUGINFO
Interferon gamma-1b
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04066:HIF-1 signaling pathway
KEGGPATH
hsa04380:Osteoclast differentiation
KEGGPATH
hsa04630:Jak-STAT signaling pathway
KEGGPATH
hsa04650:Natural killer cell mediated cytotoxicity
KEGGPATH
hsa05132:Salmonella infection
KEGGPATH
hsa05140:Leishmaniasis
KEGGPATH
hsa05142:Chagas disease (American trypanosomiasis)
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04066 |
|
| hsa04380 |
|
| hsa04630 |
|
| hsa04650 |
|
| hsa05132 |
|
| hsa05140 |
|
| hsa05142 |
|
| hsa05145 |
|
| hsa05152 |
|
| hsa05162 |
|
| hsa05164 |
|
| hsa05168 |
|
| hsa05321 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Interferon gamma receptor (IFNGR2) |
|