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靶点信息26(本栏目收费,不能显示细节,电话13136136841)

靶点信息

标题

内容

相关药物

状态

TARGETID

T30040

FORMERID

TTDR00926

UNIPROID

VEGFB_HUMAN

TARGNAME

Vascular endothelial growth factor B (VEGFB)

GENENAME

VEGFB

TARGTYPE

Successful target

SYNONYMS

VRF; VEGF-related factor; VEGF-B

FUNCTION

VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. Growth factor for endothelial cells.

PDBSTRUC

2XAC; 2VWE; 2C7W

BIOCLASS

Growth factor

SEQUENCE

MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA

DRUGINFO

D0C9ET

Aflibercept

Approved

KEGGPATH

hsa04014:Ras signaling pathway

KEGGPATH

hsa04015:Rap1 signaling pathway

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04510:Focal adhesion

KEGGPATH

hsa05200:Pathways in cancer

WIKIPATH

WP1591:Heart Development

WIKIPATH

WP1919:Signaling by VEGF

目标的 KEGG 通路数据

标题	内容
hsa04014	Ras signaling pathway
hsa04015	Rap1 signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04151	PI3K-Akt signaling pathway
hsa04510	Focal adhesion
hsa05200	Pathways in cancer

目标的 Wiki 路径数据

标题	内容
WP306	Focal Adhesion
WP1919	Signaling by VEGF
WP1591	Heart Development

目标的蛋白质ID

标题	内容
TARGETID	T30040
UNIPROID	VEGFB_HUMAN
TARGNAME	Vascular endothelial growth factor B (VEGFB)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Vascular endothelial growth factor B (VEGFB)	MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA

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