靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T29500

FORMERID

TTDS00029

UNIPROID

ADA1B_HUMAN

TARGNAME

Adrenergic receptor alpha-1B (ADRA1B)

GENENAME

ADRA1B

TARGTYPE

Successful target

SYNONYMS

Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor; Alpha-1B adrenergic receptor; Alpha 1B-adrenoreceptor; Alpha 1B-adrenoceptor

FUNCTION

Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF

DRUGINFO

Methamphetamine

DRUGINFO

Methoxamine

DRUGINFO

Phendimetrazine

DRUGINFO

Propericiazine

DRUGINFO

MEDETOMIDINE

DRUGINFO

Sunepitron

Discontinued in Phase 3

DRUGINFO

D01RCS

TIOSPIRONE

Discontinued in Phase 3

DRUGINFO

D01WJZ

MAZAPERTINE

Discontinued in Phase 2

DRUGINFO

D08OJU

SOU-001

Discontinued in Phase 2

DRUGINFO

D0U3HP

ABANOQUIL

Terminated

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04270	Vascular smooth muscle contraction
hsa04970	Salivary secretion

目标的 Wiki 路径数据

标题	内容
WP58	Monoamine GPCRs
WP536	Calcium Regulation in the Cardiac Cell
WP455	GPCRs, Class A Rhodopsin-like
WP2877	Vitamin D Receptor Pathway
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling
WP1403	AMPK Signaling

目标的蛋白质ID

标题	内容
TARGETID	T29500
UNIPROID	ADA1B_HUMAN
TARGNAME	Adrenergic receptor alpha-1B (ADRA1B)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Adrenergic receptor alpha-1B (ADRA1B)	MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF

标题

内容

Adrenergic receptor alpha-1B (ADRA1B)

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