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靶点信息

标题

内容

相关药物

状态

TARGETID

T29143

FORMERID

TTDC00177

UNIPROID

IL13_HUMAN

TARGNAME

Interleukin-13 (IL13)

GENENAME

IL13

TARGTYPE

Clinical trial target

SYNONYMS

NC30; IL-13

FUNCTION

Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. Cytokine.

PDBSTRUC

5L6Y; 5E4E; 4PS4; 4I77; 3LB6

BIOCLASS

Cytokine: interleukin

SEQUENCE

MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN

DRUGINFO

Lebrikizumab

DRUGINFO

Tralokinumab

DRUGINFO

Anrukinzumab

DRUGINFO

Dectrekumab

DRUGINFO

PEGylated pitrakinra

DRUGINFO

QAX-576

DRUGINFO

Romilkimab

DRUGINFO

SAR-156597

DRUGINFO

CNTO-5825

目标的 KEGG 通路数据

标题	内容
hsa04060	Cytokine-cytokine receptor interaction
hsa04630	Jak-STAT signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa05162	Measles
hsa05310	Asthma
hsa05321	Inflammatory bowel disease (IBD)

目标的 Wiki 路径数据

标题	内容
WP706	SIDS Susceptibility Pathways
WP530	Cytokines and Inflammatory Response
WP2328	Allograft Rejection

目标的蛋白质ID

标题	内容
TARGETID	T29143
UNIPROID	IL13_HUMAN
TARGNAME	Interleukin-13 (IL13)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Interleukin-13 (IL13)	MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN

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