TARGETID

T24555

FORMERID

TTDI02256

UNIPROID

ADRB2_HUMAN

TARGNAME

ADRB2 messenger RNA (ADRB2 mRNA)

GENENAME

ADRB2

TARGTYPE

Clinical trial target

SYNONYMS

Beta-2 adrenoreceptor (mRNA); Beta-2 adrenoceptor (mRNA); Beta-2 adrenergic receptor (mRNA); B2AR (mRNA); ADRB2R (mRNA)

FUNCTION

The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.

PDBSTRUC

6MXT; 5X7D; 5JQH; 5D6L; 5D5B

BIOCLASS

mRNA target

SEQUENCE

MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

DRUGINFO

Bamosiran

DRUGINFO

SYL-040012

KEGGPATH

hsa04020:Calcium signaling pathway

KEGGPATH

hsa04022:cGMP-PKG signaling pathway

KEGGPATH

hsa04024:cAMP signaling pathway

KEGGPATH

hsa04080:Neuroactive ligand-receptor interaction

KEGGPATH

hsa04144:Endocytosis

KEGGPATH

hsa04261:Adrenergic signaling in cardiomyocytes

KEGGPATH

hsa04970:Salivary secretion