靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T23797

FORMERID

TTDI02101

UNIPROID

IL33_HUMAN

TARGNAME

Interleukin-33 (IL33)

GENENAME

IL33

TARGTYPE

Clinical trial target

SYNONYMS

Nuclear factor from high endothelial venules; NFHEV; NF-HEV; Interleukin1 family member 11; Interleukin-1 family member 11; IL1F11; IL-33; IL-1F11; C9orf26

FUNCTION

Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury. Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells.

PDBSTRUC

4KC3; 2KLL

BIOCLASS

Cytokine: interleukin

SEQUENCE

MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNHLALIKVDSSENLCTENILFKLSET

DRUGINFO

D07GDR

AMG 282

Phase 1

KEGGPATH

hsa04623:Cytosolic DNA-sensing pathway

KEGGPATH

hsa05164:Influenza A

目标的 KEGG 通路数据

标题	内容
hsa04623	Cytosolic DNA-sensing pathway
hsa05164	Influenza A

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T23797
UNIPROID	IL33_HUMAN
TARGNAME	Interleukin-33 (IL33)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Interleukin-33 (IL33)	MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNHLALIKVDSSENLCTENILFKLSET

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