靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T23714

FORMERID

TTDC00111

UNIPROID

BKRB2_HUMAN

TARGNAME

B2 bradykinin receptor (BDKRB2)

GENENAME

BDKRB2

TARGTYPE

Successful target

SYNONYMS

Bradykinin B2 receptor; BKR2; BK-2 receptor; BK B(2) receptor; B2R

FUNCTION

It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Receptor for bradykinin.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ

DRUGINFO

Icatibant

DRUGINFO

Anatibant

DRUGINFO

DELTIBANT

DRUGINFO

DM199

DRUGINFO

Fasitibant chloride

DRUGINFO

BRADYKININ

DRUGINFO

Labradimil

Discontinued in Phase 2

DRUGINFO

D03ZBM

NPC-567

Discontinued in Phase 2

DRUGINFO

CP-0597

DRUGINFO

FR-172357

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04610	Complement and coagulation cascades
hsa04750	Inflammatory mediator regulation of TRP channels
hsa04810	Regulation of actin cytoskeleton
hsa04961	Endocrine and other factor-regulated calcium reabsorption
hsa05142	Chagas disease (American trypanosomiasis)
hsa05200	Pathways in cancer

目标的 Wiki 路径数据

标题	内容
WP554	ACE Inhibitor Pathway
WP51	Regulation of Actin Cytoskeleton
WP455	GPCRs, Class A Rhodopsin-like
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP259	Nifedipine Activity
WP24	Peptide GPCRs
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling

目标的蛋白质ID

标题	内容
TARGETID	T23714
UNIPROID	BKRB2_HUMAN
TARGNAME	B2 bradykinin receptor (BDKRB2)
TARGTYPE	Successful target

目标的序列数据

标题	内容
B2 bradykinin receptor (BDKRB2)	MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ

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