TARGETID

T22658

FORMERID

TTDR00205

UNIPROID

IL8_HUMAN

TARGNAME

Interleukin-8 (IL8)

GENENAME

CXCL8

TARGTYPE

Successful target

SYNONYMS

T-cell chemotactic factor; Protein 3-10C; Neutrophil-activating protein 1; NAP-1; Monocyte-derived neutrophil-activating peptide; Monocyte-derived neutrophil chemotactic factor; MONAP; MDNCF; IL8; IL-8; Granulocyte chemotactic protein 1; GCP-1; Emoctakin; Chemokine (C-X-C motif) ligand 8; C-X-C motif chemokine 8

FUNCTION

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

PDBSTRUC

5WDZ; 5D14; 4XDX; 3IL8; 2IL8

BIOCLASS

Cytokine: interleukin

SEQUENCE

MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

DRUGINFO

Ibuprofen

DRUGINFO

ABX-IL8

DRUGINFO

BMS-986253

DRUGINFO

MDX-018

DRUGINFO

R-ketoprofen

DRUGINFO

2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid

DRUGINFO

2-(2-(2-chlorophenoxy)phenyl)acetic acid

DRUGINFO

2-(2-(2-chlorophenylamino)phenyl)acetic acid

DRUGINFO

2-(2-(2-fluorophenoxy)phenyl)acetic acid