靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T22118

FORMERID

TTDS00011

UNIPROID

DRD1_HUMAN

TARGNAME

Dopamine D1 receptor (D1R)

GENENAME

DRD1

TARGTYPE

Successful target

SYNONYMS

D(1A) dopamine receptor

FUNCTION

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

PDBSTRUC

1OZ5

BIOCLASS

GPCR rhodopsin

SEQUENCE

MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT

DRUGINFO

Fenoldopam

DRUGINFO

Methylergonovine

DRUGINFO

Pergolide

DRUGINFO

Phenyltoloxamine

DRUGINFO

Ecopipam

DRUGINFO

Zicronapine

DRUGINFO

DAS-431

DRUGINFO

Dihydrexidine

DRUGINFO

ADROGOLIDE HYDROCHLORIDE

Discontinued in Phase 2

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04024	cAMP signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04540	Gap junction
hsa04728	Dopaminergic synapse
hsa05012	Parkinson's disease
hsa05030	Cocaine addiction
hsa05031	Amphetamine addiction
hsa05032	Morphine addiction
hsa05034	Alcoholism

目标的 Wiki 路径数据

标题	内容
WP666	Hypothetical Network for Drug Addiction
WP58	Monoamine GPCRs
WP455	GPCRs, Class A Rhodopsin-like
WP2636	Genes and (Common) Pathways Underlying Drug Addiction
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling

目标的蛋白质ID

标题	内容
TARGETID	T22118
UNIPROID	DRD1_HUMAN
TARGNAME	Dopamine D1 receptor (D1R)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Dopamine D1 receptor (D1R)	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT

标题

内容

Dopamine D1 receptor (D1R)

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