TARGETID

T21434

FORMERID

TTDC00242

UNIPROID

ACH10_HUMAN

TARGNAME

Neuronal acetylcholine receptor alpha-10 (CHRNA10)

GENENAME

CHRNA10

TARGTYPE

Clinical trial target

SYNONYMS

Nicotinic acetylcholine receptor subunit alpha 10; NACHR alpha 10; CHRNA10

FUNCTION

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes thecell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

BIOCLASS

Neurotransmitter receptor

SEQUENCE

MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL

DRUGINFO

ACV-1

DRUGINFO

[3H]methyllycaconitine

KEGGPATH

hsa04080:Neuroactive ligand-receptor interaction

PANTPATH

P00044:Nicotinic acetylcholine receptor signaling pathway