TARGETID

T20401

FORMERID

TTDS00306

UNIPROID

CAH2_HUMAN

TARGNAME

Carbonic anhydrase II (CA-II)

GENENAME

CA2

TARGTYPE

Successful target

SYNONYMS

Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC

FUNCTION

Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation.

PDBSTRUC

9CA2; 8CA2; 7CA2; 6QEB; 6MBY

BIOCLASS

Alpha-carbonic anhydrase

ECNUMBER

EC 4.2.1.1

SEQUENCE

MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK

DRUGINFO

Benzthiazide

DRUGINFO

Chlorothiazide

DRUGINFO

Cyclothiazide

DRUGINFO

Dichlorphenamide

DRUGINFO

Dorzolamide

DRUGINFO

Ethinamate

DRUGINFO

Ethoxzolamide

DRUGINFO

Salicyclic acid