TARGETID

T19160

FORMERID

TTDC00025

UNIPROID

PA2GA_HUMAN

TARGNAME

Group IIA phospholipase A2 (GIIA sPLA2)

GENENAME

PLA2G2A

TARGTYPE

Clinical trial target

SYNONYMS

RASF-A; Phospholipase A2, membrane associated; Phosphatidylcholine 2-acylhydrolase 2A; PLA2L; PLA2B; Non-pancreatic secretory phospholipase A2; NPS-PLA2; GIIC sPLA2

FUNCTION

Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner.

PDBSTRUC

5G3N; 3U8I; 3U8H; 3U8D; 3U8B

BIOCLASS

Carboxylic ester hydrolase

ECNUMBER

EC 3.1.1.4

SEQUENCE

MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC

DRUGINFO

KH064

DRUGINFO

1,4-Butanediol

DRUGINFO

2-(4-phenoxyphenoxy)ethanamine

DRUGINFO

2-Propanol, Isopropanol

DRUGINFO

B-Octylglucoside

DRUGINFO

BOLINAQUINONE

DRUGINFO

CACOSPONGIONOLIDE

DRUGINFO

CACOSPONGIONOLIDE B