TARGETID

T18972

FORMERID

TTDNC00504

UNIPROID

CD3G_HUMAN

TARGNAME

T-cell surface glycoprotein CD3 gamma (CD3G)

GENENAME

CD3G

TARGTYPE

Clinical trial target

SYNONYMS

T3G; T-cell surface glycoprotein CD3 gamma chain; T-cell receptor T3 gamma chain; CD3g

FUNCTION

When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.

PDBSTRUC

1SY6

SEQUENCE

MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN

DRUGINFO

Teplizumab

DRUGINFO

Ertumaxomab

DRUGINFO

IMCgp100

DRUGINFO

MGD007

DRUGINFO

Autologous T-cell therapy

DRUGINFO

MEDI-565

DRUGINFO

MT-110

KEGGPATH

hsa04640:Hematopoietic cell lineage

KEGGPATH

hsa04660:T cell receptor signaling pathway

KEGGPATH

hsa05142:Chagas disease (American trypanosomiasis)