靶点信息70(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Monoglyceride lipase (MAGL)
TARGTYPE
Clinical trial target
SYNONYMS
Monoacylglycerol lipase; MGL; Lysophospholipaselike; Lysophospholipase-like; Lysophospholipase homolog; HUK5; HU-K5
FUNCTION
Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. Converts monoacylglycerides to free fatty acids and glycerol.
PDBSTRUC
6BQ0; 6AX1; 5ZUN; 4UUQ; 3PE6
BIOCLASS
Carboxylic ester hydrolase
SEQUENCE
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
DRUGINFO
Azetidine-benzoxazin-3(4H)-one derivative 1
DRUGINFO
Azetidine-benzoxazin-3(4H)-one derivative 2
DRUGINFO
Azetidine-benzoxazin-3(4H)-one derivative 3
DRUGINFO
Azetidinyl-piperazine derivative 1
DRUGINFO
Azetidinyl-piperazine derivative 2
DRUGINFO
Azetidinyl-piperazine derivative 3
DRUGINFO
Azetidinyl-piperidine derivative 1
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa00561 |
|
| hsa01100 |
|
| hsa04723 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP2764 |
|
| WP2740 |
|
| WP1824 |
|
| WP1809 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Monoglyceride lipase (MAGL) |
|