TARGETID

T18299

FORMERID

TTDI02008

UNIPROID

KCC2A_HUMAN; KCC2B_HUMAN; KCC2D_HUMAN; KCC2G_HUMAN

TARGNAME

CaM-kinase II (CAMK2)

GENENAME

CAMK2A; CAMK2B; CAMK2D; CAMK2G

TARGTYPE

Clinical trial target

SYNONYMS

Calcium/calmodulin-dependent protein kinase type II; CaMK-II; CaM kinase II; CAMK

FUNCTION

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.

BIOCLASS

Kinase

SEQUENCE

MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH

DRUGINFO

Rimacalib

DRUGINFO

ABIO 09-01

DRUGINFO

KN-93

DRUGINFO

PMID18334293C15b

DRUGINFO

PMID18337095C27

KEGGPATH

hsa04012:ErbB signaling pathway

KEGGPATH

hsa04020:Calcium signaling pathway

KEGGPATH

hsa04024:cAMP signaling pathway

KEGGPATH

hsa04066:HIF-1 signaling pathway

KEGGPATH

hsa04114:Oocyte meiosis