靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T17758

FORMERID

TTDC00312

UNIPROID

UROK_HUMAN

TARGNAME

Urokinase-type plasminogen activator (PLAU)

GENENAME

PLAU

TARGTYPE

Successful target

SYNONYMS

UPA; U-plasminogen activator

FUNCTION

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

PDBSTRUC

6NMB; 5ZC5; 5ZAJ; 5ZAH; 5ZAG

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.21.73

SEQUENCE

MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL

DRUGINFO

Pro-urokinase

DRUGINFO

Urokinase

DRUGINFO

PAI-1

DRUGINFO

Amediplase

DRUGINFO

Saruplase

DRUGINFO

Upamostat

DRUGINFO

HTU-PA

DRUGINFO

PMID18163548C4

目标的 KEGG 通路数据

标题	内容
hsa04064	NF-kappa B signaling pathway
hsa04610	Complement and coagulation cascades
hsa05202	Transcriptional misregulation in cancer
hsa05205	Proteoglycans in cancer
hsa05206	MicroRNAs in cancer

目标的 Wiki 路径数据

标题	内容
WP710	DNA Damage Response (only ATM dependent)
WP615	Senescence and Autophagy in Cancer
WP558	Complement and Coagulation Cascades
WP474	Endochondral Ossification
WP428	Wnt Signaling Pathway
WP399	Wnt Signaling Pathway and Pluripotency
WP272	Blood Clotting Cascade
WP1802	Dissolution of Fibrin Clot
WP1434	Osteopontin Signaling

目标的蛋白质ID

标题	内容
TARGETID	T17758
UNIPROID	UROK_HUMAN
TARGNAME	Urokinase-type plasminogen activator (PLAU)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Urokinase-type plasminogen activator (PLAU)	MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL

标题

内容

Urokinase-type plasminogen activator (PLAU)

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