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靶点信息24(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Platelet glycoprotein Ib alpha (CD42b)
TARGTYPE
Clinical trial target
SYNONYMS
Platelet glycoprotein Ib alpha chain; Glycoprotein Ibalpha; Glycocalicin; GPIbalpha; GPIbA; GPIb-alpha; GPIb alpha; GP-Ib alpha; Antigen CD42balpha; Antigen CD42b-alpha
FUNCTION
GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
PDBSTRUC
4YR6; 4MGX; 4CH8; 4CH2; 4C2B
SEQUENCE
MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQTTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLSTVSIRYSGHSL
KEGGPATH
hsa04512:ECM-receptor interaction
KEGGPATH
hsa04611:Platelet activation
KEGGPATH
hsa04640:Hematopoietic cell lineage
WIKIPATH
WP1818:Formation of Fibrin Clot (Clotting Cascade)
WIKIPATH
WP1823:GP1b-IX-V activation signalling
WIKIPATH
WP1883:Platelet Adhesion to exposed collagen
WIKIPATH
WP1884:Platelet Aggregation (Plug Formation)
REACPATH
R-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04512 |
|
| hsa04611 |
|
| hsa04640 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP1884 |
|
| WP1883 |
|
| WP1823 |
|
| WP1818 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Platelet glycoprotein Ib alpha (CD42b) |
|