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靶点信息44(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Dihydrofolate reductase (DHFR)
TARGTYPE
Successful target
FUNCTION
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. Key enzyme in folate metabolism.
PDBSTRUC
6DE4; 6DAV; 6A7E; 6A7C; 5HVE
BIOCLASS
CH-NH donor oxidoreductase
SEQUENCE
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
DRUGINFO
Aminosalicylic Acid
DRUGINFO
Leucovorin Calcium
DRUGINFO
Methotrexate Sodium
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa00670 |
|
| hsa00790 |
|
| hsa01100 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP404 |
|
| WP2525 |
|
| WP2446 |
|
| WP241 |
|
| WP1857 |
|
| WP1850 |
|
| WP176 |
|
| WP1601 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Dihydrofolate reductase (DHFR) |
|