靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T16868

FORMERID

TTDC00137

UNIPROID

CADH2_HUMAN

TARGNAME

Neural cadherin (CDH2)

GENENAME

CDH2

TARGTYPE

Clinical trial target

SYNONYMS

NCAD; N-cadherin; Cadherin-2; CDw325; CDHN; CD325

FUNCTION

Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell.

BIOCLASS

Cadherin protein

SEQUENCE

MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESVKESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD

DRUGINFO

D0KK9E

Exherin

Phase 2

KEGGPATH

hsa04514:Cell adhesion molecules (CAMs)

KEGGPATH

hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC)

WIKIPATH

WP1793:Cell junction organization

WIKIPATH

WP2064:Neural Crest Differentiation

WIKIPATH

WP2118:Arrhythmogenic Right Ventricular Cardiomyopathy

WIKIPATH

WP2380:BDNF signaling pathway

WIKIPATH

WP2572:Primary Focal Segmental Glomerulosclerosis FSGS

REACPATH

R-HSA-375170:CDO in myogenesis

REACPATH

R-HSA-418990:Adherens junctions interactions

目标的 KEGG 通路数据

标题	内容
hsa04514	Cell adhesion molecules (CAMs)
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)

目标的 Wiki 路径数据

标题	内容
WP2572	Primary Focal Segmental Glomerulosclerosis FSGS
WP2380	BDNF signaling pathway
WP2118	Arrhythmogenic Right Ventricular Cardiomyopathy
WP2064	Neural Crest Differentiation
WP1793	Cell junction organization

目标的蛋白质ID

标题	内容
TARGETID	T16868
UNIPROID	CADH2_HUMAN
TARGNAME	Neural cadherin (CDH2)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Neural cadherin (CDH2)	MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESVKESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD

标题

内容

Neural cadherin (CDH2)

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