靶点信息18(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Iodothyronine deiodinase type I (DIO1)
TARGTYPE
Successful target
SYNONYMS
Type-I 5'-deiodinase; Type I iodothyronine deiodinase; Type 1 DI; TXDI1; ITDI1; DIOI; 5DI
FUNCTION
Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).
SEQUENCE
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEVRAVLEKLHS
DRUGINFO
Propylthiouracil
KEGGPATH
hsa04919:Thyroid hormone signaling pathway
WIKIPATH
WP15:Selenium Micronutrient Network
WIKIPATH
WP2693:Metabolism of amino acids and derivatives
WIKIPATH
WP28:Selenium Metabolism and Selenoproteins
BIOCPATH
PWY-6260:Thyroid hormone metabolism I (via deiodination)
BIOCPATH
PWY-6261:Thyroid hormone metabolism II (via conjugation and/or degradation)
BIOCPATH
PWY-6688:Thyronamine and iodothyronamine metabolism
目标的蛋白质ID
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目标的序列数据
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| Iodothyronine deiodinase type I (DIO1) |
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