TARGETID

T16691

FORMERID

TTDC00185

UNIPROID

5HT6R_HUMAN

TARGNAME

5-HT 6 receptor (HTR6)

GENENAME

HTR6

TARGTYPE

Clinical trial target

SYNONYMS

Serotonin receptor 6; 5-hydroxytryptamine receptor 6; 5-HT6 receptor; 5-HT6; 5-HT-6

FUNCTION

The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. Is an activator of TOR signaling. This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN

DRUGINFO

LU AE58054

DRUGINFO

SB-742457

DRUGINFO

AVN 211

DRUGINFO

AVN 101

DRUGINFO

AVN 322

DRUGINFO

PF-05212377

DRUGINFO

SAM-531

DRUGINFO

SUVN-502

DRUGINFO

SYN120

DRUGINFO

SYN-120