TARGETID

T16347

FORMERID

TTDI01934

UNIPROID

PTN1_HUMAN

TARGNAME

Protein-tyrosine phosphatase 1B (PTP1B)

GENENAME

PTPN1

TARGTYPE

Clinical trial target

SYNONYMS

Tyrosine-protein phosphatase non-receptor type 1; PTP-1B

FUNCTION

Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response.

PDBSTRUC

6CWV; 6CWU; 6BAI; 6B95; 6B90

BIOCLASS

Phosphoric monoester hydrolase

ECNUMBER

EC 3.1.3.48

SEQUENCE

MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT

DRUGINFO

IONIS-PTP1BRX

DRUGINFO

TTP-814

DRUGINFO

KQ-791

DRUGINFO

Trodusquemine

DRUGINFO

JTT-551

KEGGPATH

hsa04520:Adherens junction

KEGGPATH

hsa04910:Insulin signaling pathway

WIKIPATH

WP1832:Integrin alphaIIb beta3 signaling