靶点信息32(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Rotamase Pin1 (PIN1)
TARGTYPE
Clinical trial target
SYNONYMS
Prolyl isomerase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl prolyl cis/trans isomerase Pin1; PPIase Pin1
FUNCTION
By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (, Ref. 21). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner. Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN. May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs.
PDBSTRUC
6DUN; 5VTK; 5VTJ; 5VTI; 5UY9
BIOCLASS
Cis-trans-isomerase
SEQUENCE
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
DRUGINFO
Avastin+/-Tarceva
DRUGINFO
(R)-2-(2-naphthamido)-3-m-tolylpropanoic acid
DRUGINFO
(R)-2-(2-naphthamido)-3-p-tolylpropanoic acid
DRUGINFO
(R)-2-(2-naphthamido)-5-phenylpent-4-ynoic acid
DRUGINFO
(R)-3-(2-naphthamido)-4-m-tolylbutanoic acid
DRUGINFO
(R,)-2-(2-naphthamido)-5-phenylpent-4-enoic acid
DRUGINFO
3,6,9,12,15,18-HEXAOXAICOSANE
DRUGINFO
Ac-Bth-Thr(PO3H2)-Pip-Nal-Gln-NH2
目标的蛋白质ID
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Rotamase Pin1 (PIN1) |
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