TARGETID

T16263

FORMERID

TTDI02037

UNIPROID

CCL5_HUMAN

TARGNAME

T-cell-specific protein RANTES (CCL5)

GENENAME

CCL5

TARGTYPE

Clinical trial target

SYNONYMS

Tcellspecific protein RANTES; TCP228; T cellspecific protein P228; T cell-specific protein P228; Smallinducible cytokine A5; Small-inducible cytokine A5; SISdelta; SIS-delta; SCYA5; RANTES(468); Eosinophil chemotactic cytokine; EoCP; D17S136E; CC motif chemokine 5; C-C motif chemokine 5

FUNCTION

Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Chemoattractant for blood monocytes, memory T-helper cells and eosinophils.

PDBSTRUC

6FGP; 6C6D; 5UIW; 5L2U; 5DNF

BIOCLASS

Cytokine: CC chemokine

SEQUENCE

MKVSAAALAVILIATALCAPASASPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS

DRUGINFO

NI-0701

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04062:Chemokine signaling pathway

KEGGPATH

hsa04620:Toll-like receptor signaling pathway

KEGGPATH

hsa04621:NOD-like receptor signaling pathway

KEGGPATH

hsa04623:Cytosolic DNA-sensing pathway

KEGGPATH

hsa04668:TNF signaling pathway

KEGGPATH

hsa05020:Prion diseases

KEGGPATH

hsa05120:Epithelial cell signaling in Helicobacter pylori infection