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靶点信息16(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
B7-related protein 1 (B7RP1)
TARGTYPE
Clinical trial target
SYNONYMS
KIAA0653; ICOSL; ICOS ligand; CD275; B7related protein 1; B7like protein Gl50; B7RP-1; B7H2; B7-like protein Gl50; B7-H2; B7 homolog 2
FUNCTION
Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. Ligand for the T-cell-specific cell surface receptor ICOS.
SEQUENCE
MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTGHV
KEGGPATH
hsa04514:Cell adhesion molecules (CAMs)
KEGGPATH
hsa04672:Intestinal immune network for IgA production
WIKIPATH
WP1799:Costimulation by the CD28 family
REACPATH
R-HSA-388841:Costimulation by the CD28 family
目标的蛋白质ID
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| UNIPROID |
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目标的序列数据
| 标题 | 内容 |
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| B7-related protein 1 (B7RP1) |
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