TARGETID

T15797

FORMERID

TTDI00213

UNIPROID

SMYD2_HUMAN

TARGNAME

SET and MYND domain-containing protein 2 (SMYD2)

GENENAME

SMYD2

TARGTYPE

Preclinical target

SYNONYMS

Nlysine methyltransferase SMYD2; N-lysine methyltransferase SMYD2; Lysine Nmethyltransferase 3C; Lysine N-methyltransferase 3C; KMT3C; Histone methyltransferase SMYD2; HSKMB; HSKM-B

FUNCTION

Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1.

PDBSTRUC

6MON; 6CBY; 6CBX; 5WCG; 5V3H

BIOCLASS

Methyltransferase

ECNUMBER

EC 2.1.1.-

SEQUENCE

MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH

DRUGINFO

A-893

DRUGINFO

AZ505

DRUGINFO

BAY 598

DRUGINFO

EPZ032597

DRUGINFO

EPZ033294

DRUGINFO

LLY-507

WIKIPATH

WP2369:Histone Modifications

REACPATH

R-HSA-3214841:PKMTs methylate histone lysines