TARGETID

T15556

FORMERID

TTDR00556

UNIPROID

PAI1_HUMAN

TARGNAME

Endothelial plasminogen activator inhibitor (SERPINE1)

GENENAME

SERPINE1

TARGTYPE

Clinical trial target

SYNONYMS

Serpin E1; Plasminogen activator inhibitor type 1; Plasminogen activator inhibitor 1; PLANH1; PAI1; PAI-1

FUNCTION

Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis. Serine protease inhibitor.

PDBSTRUC

9PAI; 6I8S; 5ZLZ; 5BRR; 4IC0

BIOCLASS

Serpin protein

SEQUENCE

MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP

DRUGINFO

THR-18

DRUGINFO

DIAPLASININ

DRUGINFO

XR-5118

DRUGINFO

AR-HO29953XX

DRUGINFO

SIDEROXYLONAL A

DRUGINFO

SIDEROXYLONAL B

DRUGINFO

Sideroxylonal C

KEGGPATH

hsa04066:HIF-1 signaling pathway

KEGGPATH

hsa04115:p53 signaling pathway