靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T15494

FORMERID

TTDC00345

UNIPROID

GHR_HUMAN

TARGNAME

GHR messenger RNA (GHR mRNA)

GENENAME

GHR

TARGTYPE

Clinical trial target

SYNONYMS

Somatotropin receptor (mRNA); Serum bindingprotein (mRNA); Growth hormone receptor (mRNA); GH receptor (mRNA)

FUNCTION

On ligand binding, couples to the JAK2/STAT5 pathway. Receptor for pituitary gland growth hormone involved in regulating postnatal body growth.

PDBSTRUC

5OHD; 5OEK; 3HHR; 2AEW; 1KF9

BIOCLASS

mRNA target

SEQUENCE

MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP

DRUGINFO

D0W3BC

ATL1103

Phase 1

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04080:Neuroactive ligand-receptor interaction

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04630:Jak-STAT signaling pathway

WIKIPATH

WP2657:Growth hormone receptor signaling

WIKIPATH

WP2678:Prolactin receptor signaling

WIKIPATH

WP474:Endochondral Ossification

REACPATH

R-HSA-1170546:Prolactin receptor signaling

目标的 KEGG 通路数据

标题	内容
hsa04060	Cytokine-cytokine receptor interaction
hsa04080	Neuroactive ligand-receptor interaction
hsa04151	PI3K-Akt signaling pathway
hsa04630	Jak-STAT signaling pathway

目标的 Wiki 路径数据

标题	内容
WP474	Endochondral Ossification
WP2678	Prolactin receptor signaling
WP2657	Growth hormone receptor signaling

目标的蛋白质ID

标题	内容
TARGETID	T15494
UNIPROID	GHR_HUMAN
TARGNAME	GHR messenger RNA (GHR mRNA)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
GHR messenger RNA (GHR mRNA)	MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP

标题

内容

GHR messenger RNA (GHR mRNA)

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