TARGETID

T15334

FORMERID

TTDC00124

UNIPROID

CETP_HUMAN

TARGNAME

Cholesteryl ester transfer protein (CETP)

GENENAME

CETP

TARGTYPE

Clinical trial target

SYNONYMS

Lipid transfer protein I; Cholesterol ester transfer protein

FUNCTION

Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination. Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles.

PDBSTRUC

4F2A; 4EWS; 2OBD

BIOCLASS

Bactericidal permeability increasing protein

SEQUENCE

MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS

DRUGINFO

Anacetrapib

DRUGINFO

Dalcetrapib

DRUGINFO

Evacetrapib

DRUGINFO

DRL-17822

DRUGINFO

JTT-302

DRUGINFO

TA-8995

DRUGINFO

BAY-60-5521

DRUGINFO

CETi-1

DRUGINFO

Torcetrapib