靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T14908

FORMERID

TTDS00377

UNIPROID

CEGT_HUMAN

TARGNAME

Ceramide glucosyltransferase (UGCG)

GENENAME

UGCG

TARGTYPE

Successful target

SYNONYMS

UGCG; UDP-glucose:N-acylsphingosine D-glucosyltransferase; UDP-glucose ceramideglucosyltransferase; Glucosylceramide synthase; GLCT-1

FUNCTION

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".

BIOCLASS

Hexosyltransferase

ECNUMBER

EC 2.4.1.80

SEQUENCE

MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV

DRUGINFO

Eliglustat tartrate

DRUGINFO

Miglustat

DRUGINFO

Venglustat

DRUGINFO

N-butylgalactonojirimycin

Investigative

KEGGPATH

hsa00600:Sphingolipid metabolism

KEGGPATH

hsa01100:Metabolic pathways

WIKIPATH

WP2788:Sphingolipid metabolism

WHIZPATH

PW000148:Sphingolipid Metabolism

REACPATH

R-HSA-1660662:Glycosphingolipid metabolism

目标的 KEGG 通路数据

标题	内容
hsa00600	Sphingolipid metabolism
hsa01100	Metabolic pathways

目标的 Wiki 路径数据

标题	内容
WP2788	Sphingolipid metabolism

目标的蛋白质ID

标题	内容
TARGETID	T14908
UNIPROID	CEGT_HUMAN
TARGNAME	Ceramide glucosyltransferase (UGCG)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Ceramide glucosyltransferase (UGCG)	MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV

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