靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T14834

FORMERID

TTDR00443

UNIPROID

PA24A_HUMAN

TARGNAME

Cytosolic phospholipase A2 (GIVA cPLA2)

GENENAME

PLA2G4A

TARGTYPE

Clinical trial target

SYNONYMS

Phospholipase A2 group IVA; PLA2G4; CPLA2

FUNCTION

Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid.

PDBSTRUC

1RLW; 1CJY; 1BCI

BIOCLASS

Carboxylic ester hydrolase

SEQUENCE

MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETEEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQNPSRCSVSLSNVEARRFFNKEFLSKPKA

DRUGINFO

ZPL521

DRUGINFO

EFIPLADIB

DRUGINFO

(S)-Ethyl 6-(2-oxohexadecanamido)decanoate

Investigative

DRUGINFO

D0K2PI

(S)-Methyl 4-(2-oxohexadecanamido)octanoate

Investigative

DRUGINFO

D0U1YU

(S)-tert-Butyl 4-(2-oxohexadecanamido)pentanoate

Investigative

DRUGINFO

D0D2SE

(Z)-1,1,1,2,2,3,3-heptafluorohenicos-12-en-4-one

DRUGINFO

[3,4''']biflavone

DRUGINFO

[4',4''']-biflavone

DRUGINFO

[6,3''']biflavone

目标的 KEGG 通路数据

标题	内容
hsa00564	Glycerophospholipid metabolism
hsa00565	Ether lipid metabolism
hsa00590	Arachidonic acid metabolism
hsa00591	Linoleic acid metabolism
hsa00592	alpha-Linolenic acid metabolism
hsa01100	Metabolic pathways
hsa04010	MAPK signaling pathway
hsa04014	Ras signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04370	VEGF signaling pathway
hsa04611	Platelet activation
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04724	Glutamatergic synapse
hsa04726	Serotonergic synapse
hsa04730	Long-term depression
hsa04750	Inflammatory mediator regulation of TRP channels
hsa04912	GnRH signaling pathway
hsa04913	Ovarian steroidogenesis
hsa04921	Oxytocin signaling pathway
hsa05231	Choline metabolism in cancer

目标的 Wiki 路径数据

标题	内容
WP98	Prostaglandin Synthesis and Regulation
WP400	p38 MAPK Signaling Pathway
WP2740	Glycerophospholipid biosynthesis
WP2650	Arachidonic acid metabolism
WP2526	PDGF Pathway
WP2377	Integrated Pancreatic Cancer Pathway
WP2324	AGE/RAGE pathway
WP1978	Opioid Signalling
WP1908	Signal amplification
WP1885	Platelet homeostasis

目标的蛋白质ID

标题	内容
TARGETID	T14834
UNIPROID	PA24A_HUMAN
TARGNAME	Cytosolic phospholipase A2 (GIVA cPLA2)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Cytosolic phospholipase A2 (GIVA cPLA2)	MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETEEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQNPSRCSVSLSNVEARRFFNKEFLSKPKA

标题

内容

Cytosolic phospholipase A2 (GIVA cPLA2)

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