TARGETID

T14755

FORMERID

TTDR00284

UNIPROID

CD40L_HUMAN

TARGNAME

TNF related activation protein (CD40LG)

GENENAME

CD40LG

TARGTYPE

Clinical trial target

SYNONYMS

Tumor necrosis factor ligand superfamily member 5; TRAP; TNFSF5; TNF-related activation protein; T-cell antigen Gp39; T cell antigen Gp39; CD40L; CD40-L; CD40 ligand; CD154 antigen; CD154

FUNCTION

Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. Cytokine that binds to CD40/TNFRSF5.

PDBSTRUC

6BRB; 3QD6; 3LKJ; 1I9R; 1ALY

BIOCLASS

Cytokine: tumor necrosis factor

SEQUENCE

MIETYNQTSPRSAATGLPISMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL

DRUGINFO

BI 655064

DRUGINFO

Dapirolizumab pegol

DRUGINFO

IL-2/CD40L-expressing leukemia vaccine

DRUGINFO

ISF35

DRUGINFO

Lucatumumab

DRUGINFO

PG-102

DRUGINFO

ABBV-428

DRUGINFO

BPX-101

DRUGINFO

CDP-7657